가와사키 환자에서의 호흡기 바이러스 감염

가와사키 환자에서의 호흡기 바이러스 감염

Respiratory virus PCR result in Kawasaki disease

(지상발표):媛
Release Date :
Seungrok Oh
Daedong Hospital Pediatrics1
오승록
대동병원 소아청소년과1

Abstract

Background: Kawasaki disease (KD) is a disease of unknown cause. TAlthough the epidemiology and clinical features of KD suggest an infectious origin, and many viral infections share similar clinical characteristics, its etiology remains unknown Methods: Medical records from patients hospitalized at Daedong hospital with the diagnosis of KD from January 1, 2012 through July 31, 2017. Throat and nasopharyngeal swabs were taken for both viral isolation and polymerase chain reaction ( PCR) for various viruses. Results: The mean age of the 62 KD cases was 2.13 years, and the male to female ratio was 1.58 (38 boys to 24 girls). Their mean fever duration was 7.5 days with a mean peak temperature of 39.7ꠑC. In addition to the typical symptoms of fever, neck lymphadenopathy, lip fissure and/or strawberry tongue, skin rash, nonpurulent bulbar conjunctivitis, finger/toe erythema, and induration followed by periungual desquamation, these KD cases also exhibited cough, rhinorrhea. Thirteen patients (21.0%) had a respiratory virus identified, including: Rhinovirus (n=5) , Adenovirus (n=3) , Coronavirus (n=3) , Bocavirus (n=2) Respiratory synctaial virus (n=1) identified by PCR. Eight patients (13.0%) had coinfection, including: Adenovirus and rhinovirus (n=4) , Adenovirus and enterovirus (n=1) , Parainfluenza virus and rhinovirus (n=1) , rhinovirus and enterovirus (n=1) , rhinovirus and coronavirus (n=1) identified by PCR. Conclusion: We found that some common respiratory viruses, such as rhinoviruses, adenoviruses, coronaviruses, and enteroviruses, were associated with KD cases.

Keywords: Kawasaki disease, Respiratory virus,